Conrad C Weihl Selected Research

Valosin Containing Protein

1/2020	Phenotypic diversity in an international Cure VCP Disease registry.
1/2019	VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.
4/2015	Altered cofactor regulation with disease-associated p97/VCP mutations.
7/2014	Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains.
3/2013	mTOR dysfunction contributes to vacuolar pathology and weakness in valosin-containing protein associated inclusion body myopathy.
12/2011	Another VCP interactor: NF is enough.
4/2010	Inclusion body myopathy, Paget's disease of the bone and fronto-temporal dementia: a disorder of autophagy.
12/2009	Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease.
5/2009	Valosin-containing protein disease: inclusion body myopathy with Paget's disease of the bone and fronto-temporal dementia.
4/2007	Transgenic expression of inclusion body myopathy associated mutant p97/VCP causes weakness and ubiquitinated protein inclusions in mice.

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Conrad C Weihl Research Topics

Disease

20	Muscular Diseases (Myopathy) 11/2021 - 01/2006
10	Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia 01/2019 - 01/2006
10	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2019 - 12/2006
8	Frontotemporal Dementia (Semantic Dementia) 01/2021 - 04/2007
7	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2019 - 08/2010
5	Dementia (Dementias) 04/2015 - 01/2006
4	Proteostasis Deficiencies 01/2020 - 03/2013
4	Nonaka type Distal myopathy 12/2019 - 02/2011
3	Muscular Dystrophies (Muscular Dystrophy) 01/2022 - 05/2014
3	Osteitis Deformans (Paget's Disease of Bone) 01/2020 - 04/2007
3	Type 1D Limb-Girdle Muscular Dystrophy 04/2019 - 07/2014
3	Necrosis 01/2019 - 12/2013
3	Starvation 08/2017 - 05/2009
2	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 11/2021 - 05/2014
2	Myositis (Idiopathic Inflammatory Myopathies) 01/2021 - 03/2009
2	Atherosclerosis 01/2020 - 01/2017
2	Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy) 01/2020 - 12/2015
2	Atherosclerotic Plaque (Atheroma) 01/2020 - 01/2017
2	Disease Progression 12/2019 - 03/2009
2	Myofibrillar Myopathy 01/2019 - 04/2015
2	Vacuolar myopathy 03/2015 - 12/2013
2	Cataract (Cataracts) 10/2013 - 03/2011
2	Alzheimer Disease (Alzheimer's Disease) 07/2013 - 10/2010
2	Huntington Disease (Huntington's Disease) 07/2013 - 02/2012
2	Parkinson Disease (Parkinson's Disease) 07/2013 - 02/2012
2	Atrophy 03/2013 - 10/2010
2	Inclusion Body Myositis 10/2010 - 03/2009
2	Motor Neuron Disease (Primary Lateral Sclerosis) 12/2006 - 08/2006
1	Facioscapulohumeral Muscular Dystrophy 01/2022
1	Weight Loss (Weight Reduction) 01/2020
1	Rhabdomyolysis 01/2019
1	Paraproteinemias (Monoclonal Gammopathy) 06/2018
1	Ophthalmoplegia (External Ophthalmoplegia) 06/2018
1	Cystinosis 09/2017

Drug/Important Bio-Agent (IBA)

25	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2006
11	Valosin Containing ProteinIBA 01/2020 - 01/2006
8	Sirolimus (Rapamycin)FDA Link 01/2019 - 05/2009
5	Protein AggregatesIBA 12/2019 - 03/2009
3	Colchicine FDA LinkGeneric 01/2017 - 10/2010
3	PrionsIBA 07/2014 - 08/2010
3	Crystallins (Crystallin)IBA 10/2013 - 03/2009
3	Ubiquitinated ProteinsIBA 10/2008 - 01/2006
2	Amino Acids FDA Link 01/2020 - 03/2013
2	Biomarkers (Surrogate Marker)IBA 12/2019 - 10/2010
2	Mechanistic Target of Rapamycin Complex 1IBA 01/2019 - 03/2013
2	ATPases Associated with Diverse Cellular ActivitiesIBA 01/2019 - 07/2014
2	DesminIBA 01/2019 - 03/2015
2	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2019 - 05/2014
2	Carbonyl Cyanide m-Chlorophenyl Hydrazone (CCCP)IBA 08/2017 - 01/2017
2	RNA-Binding Proteins (RNA-Binding Protein)IBA 12/2015 - 03/2013
2	Adrenal Cortex Hormones (Corticosteroids)IBA 05/2014 - 03/2009
2	Glycine (Aminoacetic Acid)FDA LinkGeneric 10/2013 - 03/2013
2	Biological ProductsIBA 05/2013 - 03/2011
2	polyglutamineIBA 02/2012 - 10/2008
2	CopperIBA 08/2009 - 12/2006
2	Proteasome Endopeptidase Complex (Proteasome)IBA 10/2008 - 01/2006
1	Muscle Proteins (Muscle Protein)IBA 11/2021
1	DystrophinIBA 11/2021
1	ProgranulinsIBA 01/2021
1	5'-Nucleotidase (5' Nucleotidase)IBA 01/2021
1	Dietary ProteinsIBA 01/2020
1	CateninsIBA 04/2019
1	Lithium ChlorideIBA 04/2019
1	Eosine Yellowish-(YS) (Eosin)IBA 01/2019
1	leucylleucine (Leu-Leu)IBA 01/2019
1	lipineIBA 01/2019
1	Endoplasmic Reticulum Chaperone BiPIBA 01/2019
1	Cathepsin BIBA 01/2019
1	DiglyceridesIBA 01/2019
1	DAPIIBA 01/2019
1	EstersIBA 01/2019
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2019
1	Hematoxylin (Haematoxylon)IBA 01/2019
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2019
1	Phosphates (Orthophosphate)IBA 01/2019
1	Phosphatidate PhosphataseIBA 01/2019
1	Phosphatidic Acids (Phosphatidic Acid)IBA 01/2019
1	Phosphotransferases (Kinase)IBA 01/2019
1	SaltsIBA 01/2019
1	SolutionsIBA 01/2019
1	Tamoxifen FDA LinkGeneric 01/2019
1	Transcription Factors (Transcription Factor)IBA 01/2019
1	TubulinIBA 01/2019
1	Myosin Light Chains (Myosin Essential Light Chain)IBA 01/2019
1	Small Interfering RNA (siRNA)IBA 01/2019
1	Galectin 3 (LGALS3)IBA 01/2019
1	Lysosomal-Associated Membrane Protein 1IBA 01/2019
1	Endosomal Sorting Complexes Required for TransportIBA 01/2019
1	Proline (L-Proline)FDA Link 12/2018
1	Valine (L-Valine)FDA Link 12/2018
1	Isoleucine (L-Isoleucine)FDA Link 12/2018
1	Small Heat-Shock ProteinsIBA 12/2018
1	cold agglutininsIBA 06/2018
1	AntibodiesIBA 06/2018
1	Myosin Heavy Chains (Myosin Heavy Chain)IBA 01/2018
1	Cystine (L-Cystine)IBA 09/2017
1	Cysteamine (Mercaptamine)FDA Link 09/2017

Therapy/Procedure

5	Therapeutics 01/2022 - 08/2009
2	Denervation 10/2010 - 12/2006
1	High-Protein Diet 01/2020